Life course research has a long tradition in social research but studies on migrants have been traditionally analysed only one transition at a time. The diversity and the increasing complexity of life patterns calls for a re-examination of territorial mobility aiming to underline the interrelation with different life trajectories such as student career, job experiences and family choices. Focusing on the South-North internal migration in Italy, in this analysis we apply sequence analysis to the Italian Households Longitudinal Survey (IHLS) asking whether the decision to migrate at different phases of life-course event (before or after the end of education, the entry in the labour market, before or after family formation) creates advantages or disadvantages that persist both in the short and in the long-run. The aim of this paper is threefold. Firstly, we want to stress the changes occurred in the last decades in the life patterns experienced by internal migrant in Italy. Secondly, we evaluate the influence of parental background on the different types of trajectories. Thirdly, we want to test whether different types of life trajectories can influence the occupational outcomes and the probability of (intern and intra-generational) social mobility.