This paper investigates if neighborhood characteristics such as education, unemployment and poverty level mitigate the genetic predisposition to higher educational attainment. Using polygenic score (PGS) provided by the Add-Health study, we test the existence of an interaction between neighborhood characteristics at Wave I and genetic score in shaping future educational attainment measured at Wave IV. Our preliminary results show that polygenic score has no predictive value in a deprived context, while it is strongly associated with education in neighborhoods with higher proportion of college educated parents.